SCHEMBL14700515

SCHEMBL14700515

COc1ccc(-c2ccc(OC(C)=O)cc2C)c(C)c1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 2/20 0.51
ACHE P22303 1/20 0.51
GLA P06280 3/20 0.50
ALDH1A1 P00352 3/20 0.50
LMNA P02545 2/20 0.50
F2 P00734 1/20 0.50
HPGD P15428 1/20 0.50
KDM4E B2RXH2 3/20 0.46
GAA P10253 2/20 0.46
HTT P42858 2/20 0.46
NPC1 O15118 1/20 0.46
TP53 P04637 1/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
GAPDH P04406 1/20 0.45
POLB P06746 1/20 0.45
CYP3A4 P08684 1/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5582943 0.93 ACHE (0.58) ACHEGLAALDH1A1LMNAKDM4E
SCHEMBL14700488 0.92 BACE1 (0.59) BACE1ACHEGLAALDH1A1LMNA
SCHEMBL12305402 0.88 BACE1 (0.64) BACE1ACHEALDH1A1LMNAHPGD
SCHEMBL6901954 0.84 PPARG (0.54) BACE1ACHEGLAALDH1A1LMNA
SCHEMBL14700589 0.83 NPC1 (0.54) ACHEGLAALDH1A1LMNAF2
SCHEMBL14700558 0.83 ACHE (0.49) BACE1ACHEGLAALDH1A1LMNA
SCHEMBL14700586 0.83 KMT2A (0.49) BACE1ACHEGLAALDH1A1LMNA
SCHEMBL12326180 0.82 CA1 (0.50) ACHEALDH1A1HPGDKDM4EGAA
SCHEMBL4198689 0.82 LMNA (0.55) BACE1ACHEGLAALDH1A1LMNA
SCHEMBL14700544 0.81 ACHE (0.47) BACE1ACHEGLAALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180059558-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2018-03-01 US disclosed
US-9864284-B2 Electrophotographic photosensitive member, method for manufacturing electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2018-01-09 US disclosed
US-9753385-B2 Electrophotographic photosensitive member, method for manufacturing electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2017-09-05 US disclosed
US-20160252829-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD FOR MANUFACTURING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2016-09-01 US disclosed
US-20160252830-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD FOR MANUFACTURING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2016-09-01 US disclosed
US-20130040234-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, MANUFACTURING METHOD THEREFOR AND ELECTROPHOTOGRAPHIC DEVICE FUJI ELECTRIC CO., LTD. (JP) 2013-02-14 US disclosed