Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 5/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.31 |
| ▸ | CPB1 | P15086 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | TYMS | P04818 | 1/20 | 0.30 |
| ▸ | SCN4A | P35499 | 3/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14704080 | 0.77 | CYP2E1 (0.49) | TSHRALDH1A1CYP2E1CYP2A6HCAR1 | |
| SCHEMBL13341971 | 0.75 | KDM4E (0.56) | ALDH1A1CPB2CYP1A2CYP3A4 | |
| SCHEMBL12443627 | 0.74 | CYP2E1 (0.42) | ALDH1A1GRM5GRM1CYP2E1CYP2A6 | |
| SCHEMBL13183612 | 0.73 | CYP1A2 (0.38) | TSHRALOX15GRM5GRM1CYP2E1 | |
| SCHEMBL11046359 | 0.71 | CPB1 (0.39) | TSHRALDH1A1GRM5GRM1HCAR1 | |
| SCHEMBL22185839 | 0.70 | CPB2 (0.44) | ALDH1A1GRM5CPB1CPB2 | |
| SCHEMBL22185260 | 0.70 | HTR3E (0.41) | TSHRALDH1A1ALOX15GRM5GRM1 | |
| SCHEMBL13659754 | 0.70 | KDM4E (0.38) | ALDH1A1GRM5GRM1CPB1CPB2 | |
| SCHEMBL21668008 | 0.70 | KDM2B (0.48) | HCAR1NPSR1 | |
| SCHEMBL24495988 | 0.69 | CYP2E1 (0.41) | GRM5GRM1CYP2E1CYP2A6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9284350-B2 | IAP BIR domain binding compounds | PHARMASCIENCE INC. (CA) | 2016-03-15 | — | — | US | disclosed |
| US-20130040892-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | PHARMASCIENCE INC. (CA) | 2013-02-14 | — | — | US | disclosed |
| US-20130040892-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | PHARMASCIENCE INC. (CA) | 2013-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040892-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | BIRC5, BIRC2, BIRC3 | TSHR 4828/4885ALDH1A1 4122/4885ALOX15 3323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.