Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 4/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 3/20 | 0.33 |
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.31 |
| ▸ | NAMPT | P43490 | 2/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | USP1 | O94782 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010005 | 0.92 | NPBWR1 (0.43) | NPBWR1PTGS2MCHR1PPARDPPARA | |
| SCHEMBL1008468 | 0.92 | PTGS2 (0.36) | NPBWR1PTGS2MCHR1PPARDPPARA | |
| SCHEMBL1009575 | 0.90 | NPBWR1 (0.34) | NPBWR1PTGS2MCHR1PPARDPPARA | |
| SCHEMBL1008714 | 0.90 | PTGS2 (0.35) | NPBWR1PTGS2MCHR1PPARDPPARA | |
| SCHEMBL1008459 | 0.89 | PTGS1 (0.42) | NPBWR1PTGS2PPARDPPARAPPARG | |
| SCHEMBL1062582 | 0.87 | PTGS2 (0.38) | NPBWR1PTGS2PPARDPPARAPPARG | |
| SCHEMBL1009171 | 0.87 | PTGS2 (0.33) | NPBWR1PTGS2PPARDPPARAPPARG | |
| SCHEMBL1009110 | 0.85 | PTGS2 (0.34) | NPBWR1PTGS2PPARDPPARAPPARG | |
| Hydrochloric Acid SCHEMBL1472516 | 0.85 | PTGS2 (0.33) | NPBWR1PTGS2PPARDPPARAPPARG | |
| SCHEMBL1009798 | 0.84 | IGF1R (0.38) | NPBWR1PTGS2MCHR1PTGS1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915258-B2 | Substituted 2,5-dihydro-3H-pyrazolo[4,3-C]pyridazin-3-one derivatives, preparation thereof and therapeutic use of the same | SANOFI-AVENTIS (FR) | 2011-03-29 | — | — | US | disclosed |
| US-20090281107-A1 | SUBSTITUTED 2,5-DIHYDRO-3H-PYRAZOLO[4,3-C]PYRIDAZIN-3-ONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE OF THE SAME | SANOFI-AVENTIS (FR) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281107-A1 | SUBSTITUTED 2,5-DIHYDRO-3H-PYRAZOLO[4,3-C]PYRIDAZIN-3-ONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE OF THE SAME | DHFR, DPYD, QDPR | NPBWR1 2687/4885PTGS2 560/4885MCHR1 2197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.