Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 1/20 | 0.52 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16740905 | 0.87 | PDE3B (0.64) | PARP15PARP14PARP10TNKS2PARP2 | |
| SCHEMBL31047680 | 0.78 | SERPINE1 (0.54) | PARP15PARP14PARP10TNKS2PARP2 | |
| SCHEMBL26785799 | 0.77 | PARP15 (0.58) | PARP15PARP14PARP10TNKS2PARP2 | |
| SCHEMBL29853659 | 0.77 | PARP15 (0.58) | PARP15PARP14PARP10TNKS2PARP2 | |
| SCHEMBL1376797 | 0.76 | NR3C1 (0.52) | PARP15PARP14PARP10TNKS2PARP2 | |
| SCHEMBL2249225 | 0.74 | ALDH1A1 (0.50) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL28825745 | 0.74 | PARP15 (0.49) | PARP15PARP14PARP10TNKS2PARP2 | |
| SCHEMBL12323809 | 0.74 | KDM4E (0.47) | PARP15PARP14PARP10TNKS2PARP2 | |
| SCHEMBL14867294 | 0.74 | KDM4E (0.50) | PARP15PARP14PARP10TNKS2PARP2 | |
| SCHEMBL24000796 | 0.73 | PARP15 (0.54) | PARP15PARP14PARP10TNKS2PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915288-B2 | 1-aryl-4-substituted isoquinolines | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2011-03-29 | — | — | US | disclosed |
| EP-1745024-A4 | 1-ARYL-4-SUBSTITUTED ISOQUINOLINES | NEUROGEN CORP (US) | 2008-01-09 | — | — | EP | disclosed |
| US-20070249665-A1 | 1-aryl-4-substituted isoquinolines | NEUROGEN CORPORATION (US) | 2007-10-25 | — | — | US | disclosed |
| EP-1745024-A1 | 1-ARYL-4-SUBSTITUTED ISOQUINOLINES | NEUROGEN CORPORATION (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005110991-A1 | 1-ARYL-4-SUBSTITUTED ISOQUINOLINES | NEUROGEN CORPORATION (US) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249665-A1 | 1-aryl-4-substituted isoquinolines | C3AR1, C5AR1, C5AR2 | PARP15 642/4885PARP14 583/4885PARP10 805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.