SCHEMBL14710246

SCHEMBL14710246

CCc1cc(Cl)c(Br)cc1C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 2/20 0.37
NOS3 P29474 1/20 0.35
NOS1 P29475 1/20 0.35
NOS2 P35228 1/20 0.35
LMNA P02545 2/20 0.35
TSHR P16473 2/20 0.35
GRIN2D O15399 1/20 0.34
GRIN3B O60391 1/20 0.34
GRIN1 Q05586 1/20 0.34
GRIN2A Q12879 1/20 0.34
GRIN2B Q13224 1/20 0.34
GRIN2C Q14957 1/20 0.34
GRIN3A Q8TCU5 1/20 0.34
ALDH1A1 P00352 2/20 0.34
HPGD P15428 2/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
HCAR1 Q9BXC0 1/20 0.34
GABRA1 P14867 1/20 0.33
GABRB2 P47870 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14333907 0.91 AHR (0.37) AHRNOS3NOS1NOS2LMNA
SCHEMBL14850110 0.83 GRIN2D (0.41) NOS3NOS1NOS2LMNATSHR
SCHEMBL19932056 0.81 NOS3 (0.40) NOS3NOS1NOS2TSHRGRIN2D
SCHEMBL19931606 0.79 CD44 (0.42) NOS3NOS1NOS2LMNATSHR
SCHEMBL17244913 0.79 ALDH1A1 (0.39) NOS3NOS1NOS2LMNATSHR
SCHEMBL3606718 0.79 THRB (0.44) TSHRHPGDTHRB
SCHEMBL3611499 0.78 AHR (0.33) AHRHCAR1
SCHEMBL27386556 0.77 GRIN2D (0.45) AHRLMNAGRIN2DGRIN3BGRIN1
SCHEMBL24690445 0.76 AHR (0.46) AHRLMNATSHRGRIN2DGRIN3B
SCHEMBL5014656 0.75 NOS3 (0.39) NOS3NOS1NOS2LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013025733-A1 LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS INTERMUNE, INC. (US) 2013-02-21 WO disclosed