Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 7/20 | 0.44 |
| ▸ | THRA | P10827 | 6/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | CLIC1 | O00299 | 1/20 | 0.38 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.38 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2351646 | 0.93 | THRB (0.40) | THRBTHRANPSR1PTGS2ALOX15 | |
| SCHEMBL23286929 | 0.83 | NPSR1 (0.48) | THRBTHRANPSR1PTGS2ALOX15 | |
| SCHEMBL29605526 | 0.83 | NPSR1 (0.48) | THRBTHRANPSR1PTGS2ALOX15 | |
| SCHEMBL11199538 | 0.83 | NPSR1 (0.44) | NPSR1PTGS2ALOX15RXRARXRB | |
| SCHEMBL11076027 | 0.79 | THRB (0.40) | THRBTHRAPTGS2CXCL8 | |
| SCHEMBL14432233 | 0.79 | NPSR1 (0.48) | NPSR1PTGS2ALOX15RXRARXRB | |
| SCHEMBL14710246 | 0.79 | AHR (0.37) | THRBHPGDTSHR | |
| SCHEMBL22701184 | 0.79 | THRB (0.37) | THRBTHRACXCL8HPGDTSHR | |
| SCHEMBL30028576 | 0.79 | THRB (0.40) | THRBTHRANPSR1PTGS2ALOX15 | |
| SCHEMBL23490846 | 0.79 | KDM1A (0.41) | THRBTHRANPSR1PTGS2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105673-A1 | SUBSTITUTED AMINOFURANONES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-04-29 | — | — | US | disclosed |
| US-20100105673-A1 | SUBSTITUTED AMINOFURANONES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-04-29 | — | — | US | disclosed |
| US-20100105673-A1 | SUBSTITUTED AMINOFURANONES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-04-29 | — | — | US | disclosed |
| US-20100022527-A1 | BIPHENYL SUBSTITUTED SPIROTETRONIC ACIDS AND THEIR USE FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2010-01-28 | — | — | US | disclosed |
| EP-2102180-A1 | SUBSTITUTED AMINOFURANONES AND THEIR USE | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-09-23 | — | — | EP | disclosed |
| EP-2054053-A1 | BIPHENYL SUBSTITUTED SPIROTETRONIC ACIDS AND THEIR USE FOR THE TREATMENT OF RETROVIRAL DISORDERS | AiCuris GmbH & Co. KG (DE) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008071359-A1 | SUBSTITUTED AMINOFURANONES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008071359-A1 | SUBSTITUTED AMINOFURANONES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008022725-A1 | BIPHENYL SUBSTITUTED SPIROTETRONIC ACIDS AND THEIR USE FOR THE TREATMENT OF RETROVIRAL DISORDERS | AICURIS GMBH & CO. KG (DE) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022527-A1 | BIPHENYL SUBSTITUTED SPIROTETRONIC ACIDS AND THEIR USE FOR THE TREATMENT OF RETROVIRAL DISEASES | DHFR, RORA, CYP2A6 | THRB 245/4885THRA 190/4885NPSR1 1530/4885 |
| US-20100105673-A1 | SUBSTITUTED AMINOFURANONES AND THEIR USE | FANCF, TPMT, AAAS | THRB 3723/4885THRA 3791/4885NPSR1 4472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.