Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2587757 | 0.99 | OPRM1 (0.56) | OPRM1OPRD1OPRK1 | |
| SCHEMBL14713294 | 0.83 | LMNA (0.55) | OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL2579712 | 0.82 | LMNA (0.57) | OPRM1OPRD1 | |
| SCHEMBL2589516 | 0.81 | LMNA (0.49) | OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL2590334 | 0.81 | LMNA (0.48) | OPRM1OPRD1OPRK1 | |
| SCHEMBL12175593 | 0.79 | OPRM1 (0.76) | OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL2579379 | 0.78 | OPRM1 (0.74) | OPRM1OPRD1OPRK1 | |
| SCHEMBL12175450 | 0.78 | OPRM1 (0.53) | OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL2589490 | 0.77 | OPRM1 (0.53) | OPRM1OPRD1OPRK1 | |
| SCHEMBL12175524 | 0.75 | OPRM1 (0.50) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859777-B2 | 4-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators | KINENTIA BIOSCIENCES LLC (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859777-B2 | 4-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators | KINENTIA BIOSCIENCES LLC (US) | 2014-10-14 | — | — | US | disclosed |
| US-20130045165-A1 | 4-FLUORO-4-ARYLPIPERDIN-1-YL DERIVATIVES AS MU OPIOID FUNCTION MODERATORS | KINENTIA BIOSCIENCES, LLC (US) | 2013-02-21 | — | — | US | disclosed |
| US-20130045165-A1 | 4-FLUORO-4-ARYLPIPERDIN-1-YL DERIVATIVES AS MU OPIOID FUNCTION MODERATORS | KINENTIA BIOSCIENCES, LLC (US) | 2013-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130045165-A1 | 4-FLUORO-4-ARYLPIPERDIN-1-YL DERIVATIVES AS MU OPIOID FUNCTION MODERATORS | OPRD1, OPRK1, OPRM1 | OPRM1 3/4885OPRD1 1/4885OPRK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.