Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 8/20 | 0.43 |
| ▸ | WHR1 | P49842 | 3/20 | 0.42 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.41 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.41 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715434 | 0.97 | EHMT2 (0.44) | EHMT2WHR1DNMT3ANSD2EZH2 | |
| SCHEMBL14715412 | 0.89 | WHR1 (0.44) | EHMT2WHR1 | |
| SCHEMBL2174116 | 0.88 | EHMT2 (0.44) | EHMT2WHR1DNMT3ANSD2EZH2 | |
| SCHEMBL14715357 | 0.85 | EHMT2 (0.45) | EHMT2WHR1DNMT3ANSD2EZH2 | |
| SCHEMBL2172163 | 0.84 | EHMT2 (0.45) | EHMT2WHR1DNMT3ANSD2EZH2 | |
| SCHEMBL14715363 | 0.82 | EHMT2 (0.44) | EHMT2WHR1DNMT3ANSD2EZH2 | |
| SCHEMBL2172172 | 0.82 | EHMT2 (0.41) | EHMT2WHR1DNMT3ANSD2EZH2 | |
| SCHEMBL14715446 | 0.80 | WHR1 (0.49) | EHMT2WHR1 | |
| SCHEMBL14715448 | 0.79 | ADRA2A (0.47) | EHMT2WHR1EHMT1 | |
| SCHEMBL2170980 | 0.79 | WHR1 (0.48) | EHMT2WHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346848-B1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |