Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715462 | 0.85 | ALDH1A1 (0.58) | ADORA2AGAASMN1; SMN2NPC1MAPT | |
| SCHEMBL14715533 | 0.85 | ALDH1A1 (0.58) | ADORA2ASMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL14715543 | 0.82 | LCK (0.49) | ADORA2ANPSR1GAAHTTMAPT | |
| SCHEMBL14715517 | 0.82 | POLB (0.58) | ADORA2ASMN1; SMN2HSD17B10L3MBTL1NPC1 | |
| SCHEMBL14715491 | 0.82 | MAPT (0.47) | ADORA2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL14715473 | 0.82 | ADORA2A (0.45) | ADORA2ANPSR1GAAHTTSMN1; SMN2 | |
| SCHEMBL5500716 | 0.79 | LCK (0.68) | MAPK14LCKKDRJAK3 | |
| SCHEMBL14715496 | 0.78 | PLAU (0.53) | NPSR1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL14715638 | 0.73 | ADORA2A (0.46) | ADORA2ANPSR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14715526 | 0.72 | TAS1R3 (0.48) | ADORA2ANPSR1HTTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |