Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.49 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | JAK3 | P52333 | 4/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715533 | 0.84 | ALDH1A1 (0.58) | ADORA2AALDH1A1KDM4EADORA3MEN1 | |
| SCHEMBL14715462 | 0.84 | ALDH1A1 (0.58) | ADORA2AALDH1A1KDM4EGAAADORA3 | |
| SCHEMBL14715519 | 0.82 | ADORA2A (0.50) | LCKKDRJAK3MAPK14ADORA2A | |
| SCHEMBL5488883 | 0.80 | LCK (0.73) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL14715473 | 0.79 | ADORA2A (0.45) | LCKKDRJAK3MAPK14ADORA2A | |
| SCHEMBL14715526 | 0.77 | TAS1R3 (0.48) | LCKKDRJAK3MAPK14ADORA2A | |
| SCHEMBL14715491 | 0.76 | MAPT (0.47) | LCKKDRJAK3MAPK14ADORA2A | |
| SCHEMBL14715517 | 0.76 | POLB (0.58) | ADORA2AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14715559 | 0.74 | POLB (0.54) | KDRTEKALDH1A1KDM4EGAA | |
| SCHEMBL14715496 | 0.71 | PLAU (0.53) | LCKKDRJAK3MAPK14TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |