Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | CCR3 | P51677 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3959812 | 1.00 | HRH1 (0.39) | HRH1CCR3POLBOPRK1SMN1; SMN2 | |
| SCHEMBL3963825 | 0.89 | HRH1 (0.46) | HRH1CCR3SMN1; SMN2KCNH2 | |
| SCHEMBL14715697 | 0.89 | HRH1 (0.46) | HRH1CCR3SMN1; SMN2KCNH2 | |
| SCHEMBL3959671 | 0.89 | HTR2A (0.40) | POLBOPRK1HTR2ADRD3NAMPT | |
| SCHEMBL3087227 | 0.84 | DRD2 (0.39) | HTR2ADRD3NAMPTHRH3 | |
| SCHEMBL3963647 | 0.84 | DRD2 (0.39) | HTR2ADRD3NAMPTHRH3 | |
| SCHEMBL3959409 | 0.84 | GPR6 (0.44) | DRD3 | |
| SCHEMBL3959814 | 0.84 | OPRK1 (0.38) | HRH1CCR3POLBOPRK1SMN1; SMN2 | |
| SCHEMBL14715685 | 0.84 | OPRK1 (0.38) | HRH1CCR3POLBOPRK1SMN1; SMN2 | |
| SCHEMBL3956550 | 0.83 | HRH1 (0.47) | HRH1CCR3SMN1; SMN2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |