Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 5/20 | 0.37 |
| ▸ | DRD3 | P35462 | 5/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3963647 | 1.00 | DRD2 (0.39) | DRD2HTR2ADRD3HTR1AGRM2 | |
| SCHEMBL3086252 | 0.86 | GRM2 (0.47) | DRD2GRM2SLC6A4HRH3 | |
| SCHEMBL14715699 | 0.86 | GRM2 (0.47) | DRD2GRM2SLC6A4HRH3 | |
| SCHEMBL3959671 | 0.84 | HTR2A (0.40) | HTR2ADRD3NAMPT | |
| SCHEMBL3959812 | 0.84 | HRH1 (0.39) | HTR2ADRD3NAMPTHRH3 | |
| SCHEMBL14715671 | 0.84 | HRH1 (0.39) | HTR2ADRD3NAMPTHRH3 | |
| SCHEMBL3093392 | 0.82 | DRD2 (0.39) | DRD2HTR2ADRD3HTR1AGRM2 | |
| SCHEMBL3959818 | 0.82 | DRD2 (0.39) | DRD2HTR2ADRD3HTR1AGRM2 | |
| SCHEMBL14715744 | 0.82 | HRH3 (0.44) | HRH3 | |
| SCHEMBL3075391 | 0.82 | HRH3 (0.44) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |
| US-7795437-B2 | Ether derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-09-14 | — | — | US | disclosed |