SCHEMBL14716409

SCHEMBL14716409

Cc1ccc(C(=O)/N=N/c2nc3c(=O)[nH]c(N)nc3[nH]2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.39
XDH P47989 2/20 0.39
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
MAPT P10636 1/20 0.39
DHFR P00374 1/20 0.39
ALDH1A1 P00352 3/20 0.38
LMNA P02545 1/20 0.38
GLA P06280 1/20 0.38
PMP22 Q01453 1/20 0.38
HSD17B10 Q99714 1/20 0.38
MGAM O43451 1/20 0.36
GAA P10253 1/20 0.36
SI P14410 1/20 0.36
MGAM2 Q2M2H8 1/20 0.36
TYMS P04818 1/20 0.34
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA9 Q16790 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14716412 1.00 KDM4E (0.39) KDM4EXDHKMT2AMEN1MAPT
SCHEMBL14716707 0.83 TDP1 (0.46) KDM4EKMT2AMEN1MAPTALDH1A1
SCHEMBL12320826 0.82 MAPT (0.44) KDM4EXDHKMT2AMEN1MAPT
SCHEMBL14716410 0.81 FGFR1 (0.46) PNP
SCHEMBL14716576 0.71 ALDH1A1 (0.53) KDM4EXDHKMT2AMAPTDHFR
SCHEMBL12320442 0.71 ALDH1A1 (0.53) KDM4EXDHKMT2AMAPTDHFR
SCHEMBL12321218 0.69 TYMS (0.41) KDM4EKMT2AMEN1MAPTALDH1A1
SCHEMBL12320449 0.69 XDH (0.47) KDM4EXDHKMT2AMEN1MAPT
SCHEMBL14716709 0.69 TYMS (0.41) KDM4EKMT2AMEN1MAPTALDH1A1
SCHEMBL14716516 0.69 XDH (0.47) KDM4EXDHKMT2AMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9458515-B2 RNA including nucleoside compound, method for regulating amount of protein produced from the RNA, and nucleoside compound RIKEN (JP) 2016-10-04 US disclosed
US-20130052710-A1 RNA INCLUDING NUCLEOSIDE COMPOUND, METHOD FOR REGULATING AMOUNT OF PROTEIN PRODUCED FROM THE RNA, AND NUCLEOSIDE COMPOUND RIKEN (JP) 2013-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130052710-A1 RNA INCLUDING NUCLEOSIDE COMPOUND, METHOD FOR REGULATING AMOUNT OF PROTEIN PRODUCED FROM THE RNA, AND NUCLEOSIDE COMPOUND RNMT, NSUN2, RNGTT KDM4E 1577/4885XDH 479/4885KMT2A 2440/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.