Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.56 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.55 |
| ▸ | CTSA | P10619 | 6/20 | 0.54 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.44 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14717964 | 0.93 | CTSA (0.54) | TLR7PANK3CTSAMMEHTR2C | |
| SCHEMBL14662637 | 0.90 | PANK3 (0.50) | TLR7PANK3CTSAMMEHTR2C | |
| SCHEMBL14661952 | 0.88 | PANK3 (0.49) | TLR7PANK3CTSAMMEHTR2C | |
| SCHEMBL14662209 | 0.85 | CTSA (0.70) | CTSAMMEHPGDSMMEL1TDP1 | |
| SCHEMBL14717573 | 0.85 | HPGDS (0.62) | TLR7CTSAHPGDSMMEL1TDP1 | |
| SCHEMBL14662356 | 0.84 | CTSA (0.54) | CTSAMMEHPGDSMMEL1TDP1 | |
| SCHEMBL14717230 | 0.84 | MAPT (0.58) | TLR7CTSAMMEHPGDSMMEL1 | |
| SCHEMBL14717139 | 0.83 | MAPT (0.59) | TLR7CTSAMMEHPGDSMMEL1 | |
| SCHEMBL14662167 | 0.82 | CTSA (0.64) | TLR7PANK3CTSA | |
| SCHEMBL14662164 | 0.82 | CTSA (0.64) | TLR7PANK3CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103827098-B | The 3-(thiazole-4-carbonyl)-replaced or 3-(thiazole-2-carbonyl)-alanine derivatives and the purposes as medicine thereof | 赛诺菲 | 2016-06-15 | — | — | CN | claimed |
| EP-2736891-B1 | SUBSTITUTED 3-(THIAZOLE-4-CARBONYL)- OR 3-(THIAZOLE-2-CARBONYL)- AMINOPROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2016-04-20 | — | — | EP | claimed |
| US-9174952-B2 | Substituted 3-thiazoloamino-propionic acid derivatives and their use as pharmaceuticals | SANOFI (FR) | 2015-11-03 | — | — | US | claimed |
| US-20130053402-A1 | SUBSTITUTED 3-THIAZOLOAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2013-02-28 | — | — | US | claimed |
| CN-103827098-B | The 3-(thiazole-4-carbonyl)-replaced or 3-(thiazole-2-carbonyl)-alanine derivatives and the purposes as medicine thereof | 赛诺菲 | 2016-06-15 | — | — | CN | disclosed |
| EP-2736891-B1 | SUBSTITUTED 3-(THIAZOLE-4-CARBONYL)- OR 3-(THIAZOLE-2-CARBONYL)- AMINOPROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2016-04-20 | — | — | EP | disclosed |
| US-9174952-B2 | Substituted 3-thiazoloamino-propionic acid derivatives and their use as pharmaceuticals | SANOFI (FR) | 2015-11-03 | — | — | US | disclosed |
| WO-2014053533-A1 | USE OF SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AS PHARMACEUTICALS FOR PREVENTION/TREATMENT OF ATRIAL FIBRILLATION | SANOFI (FR) | 2014-04-10 | — | — | WO | disclosed |
| US-20130053402-A1 | SUBSTITUTED 3-THIAZOLOAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053402-A1 | SUBSTITUTED 3-THIAZOLOAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | CTSF, CTSS, CTSK | TLR7 1949/4885PANK3 2517/4885CTSA 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.