Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24854638 | 0.87 | KCNA3 (0.46) | ALDH1A1APPDRD4DRD2DRD3 | |
| SCHEMBL6557649 | 0.85 | MAOB (0.57) | KDM4EALDH1A1APPDRD4DRD2 | |
| SCHEMBL13472002 | 0.85 | ATM (0.50) | KDM4EALDH1A1APPDRD4DRD2 | |
| SCHEMBL11563384 | 0.85 | ATM (0.50) | KDM4EALDH1A1APPDRD4DRD2 | |
| SCHEMBL18235025 | 0.82 | DRD4 (0.57) | KDM4EALDH1A1APPDRD4DRD2 | |
| SCHEMBL17445905 | 0.82 | ATM (0.60) | KDM4EALDH1A1APPDRD4DRD2 | |
| SCHEMBL2642306 | 0.81 | KDM4E (0.48) | KDM4EALDH1A1APPDRD4DRD2 | |
| SCHEMBL17465617 | 0.80 | ATM (0.58) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL14031270 | 0.80 | TSHR (0.58) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL3328295 | 0.80 | APP (0.52) | KDM4EALDH1A1APPDRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846407-B1 | 7-{4-[2-(2,6-DICHLORO-4-METHYLPHENOXY)ETHOXY]PHENYL}-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE-6-CARBOXYLIC ACID CYCLOPROPYL-(2,3-DIMETHYLBENZYL)AMIDE AS INHIBITOR OF RENIN FOR THE TREATMENT OF HYPERTENSION. | ACTELION PHARMACEUTICALS LTD (CH) | 2011-06-29 | — | — | EP | disclosed |
| US-7915259-B2 | 7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylic acid cyclopropyl-(2,3-dimethylbenzyl)amide; retin inhibitor with other active ingredients; cardiovascular diseases and renal insufficiency | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-03-29 | — | — | US | disclosed |
| US-7915259-B2 | 7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylic acid cyclopropyl-(2,3-dimethylbenzyl)amide; retin inhibitor with other active ingredients; cardiovascular diseases and renal insufficiency | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-03-29 | — | — | US | disclosed |
| US-7915259-B2 | 7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylic acid cyclopropyl-(2,3-dimethylbenzyl)amide; retin inhibitor with other active ingredients; cardiovascular diseases and renal insufficiency | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-03-29 | — | — | US | disclosed |
| US-20080161313-A1 | Diazabicyclononene Derivatives and Use Thereof | ACTELION PHARMACEUTICALS LTD (CH) | 2008-07-03 | — | — | US | disclosed |
| US-20080161313-A1 | Diazabicyclononene Derivatives and Use Thereof | ACTELION PHARMACEUTICALS LTD (CH) | 2008-07-03 | — | — | US | disclosed |
| US-20080161313-A1 | Diazabicyclononene Derivatives and Use Thereof | ACTELION PHARMACEUTICALS LTD (CH) | 2008-07-03 | — | — | US | disclosed |
| EP-1846407-A1 | 7-{4-[2-(2,6-DICHLORO-4-METHYLPHENOXY)ETHOXY]PHENYL}-3,9-DIAZABICYCLO[3.3.31]NON-6-ENE-6-CARBOXYLIC ACID CYCLOPROPYL-(2,3-DIMETHYLBENZYL)AMIDE AS INHIBITORS OF RENIN FOR THE TREATMENT OF HYPERTENSION. | Actelion Pharmaceuticals Ltd. (CH) | 2007-10-24 | — | — | EP | disclosed |
| WO-2007034406-A1 | PYRROLIDINE-3-CARBOXYLIC ACID AMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF RENIN | ACTELION PHARMACEUTICALS LTD (CH) | 2007-03-29 | — | — | WO | disclosed |
| WO-2006079988-A1 | 7- {4- [2- (2 , 6-DICHL0R0-4-METHYLPHEN0XY) ETHOXY] PHENYL}-3 , 9-DIAZABICYCLO [3 .3 . 31] NON - 6-ENE- S- CARBOXYLIC ACID CYCLOPROPYL- (2 , 3-DIMETHYLBENZYD AMIDE AS INHIBITORS OF RENIN FOR THE TREATMENT OF HYPERTENSION | ACTELION PHARMACEUTICALS LTD (CH) | 2006-08-03 | — | — | WO | disclosed |
| WO-2006079988-A1 | 7- {4- [2- (2 , 6-DICHL0R0-4-METHYLPHEN0XY) ETHOXY] PHENYL}-3 , 9-DIAZABICYCLO [3 .3 . 31] NON - 6-ENE- S- CARBOXYLIC ACID CYCLOPROPYL- (2 , 3-DIMETHYLBENZYD AMIDE AS INHIBITORS OF RENIN FOR THE TREATMENT OF HYPERTENSION | ACTELION PHARMACEUTICALS LTD (CH) | 2006-08-03 | — | — | WO | disclosed |
| WO-2006021403-A1 | BICYCLONONENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161313-A1 | Diazabicyclononene Derivatives and Use Thereof | REN, ACE, AGTR1 | KDM4E 2878/4885ALDH1A1 221/4885APP 1485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.