Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.35 |
| ▸ | NOS1 | P29475 | 3/20 | 0.35 |
| ▸ | NOS2 | P35228 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.31 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.31 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL19644046 | 0.87 | — | — | |
| Guanidine SCHEMBL28861357 | 0.83 | — | — | |
| Lindane SCHEMBL9845655 | 0.79 | LMNA (0.50) | TSHRTDP1LMNACYP3A4GABRA1 | |
| Thiourea SCHEMBL9175288 | 0.73 | — | — | |
| Guanidine SCHEMBL28137273 | 0.71 | — | — | |
| Butane SCHEMBL10941992 | 0.68 | — | — | |
| Guanidine SCHEMBL5531666 | 0.68 | — | — | |
| Lindane SCHEMBL10416102 | 0.68 | ALDH1A1 (0.55) | TSHRLMNACYP3A4GABRA1GABRB1 | |
| Guanidine SCHEMBL1933907 | 0.68 | — | — | |
| Guanidine SCHEMBL27509592 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190153160-A1 | POLYETHERIMIDE COMPOSITIONS AND METHODS FOR THE MANUFACTURE AND USE THEREOF | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2019-05-23 | — | — | US | disclosed |
| US-10227452-B2 | Polyetherimide compositions and methods for the manufacture and use thereof | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2019-03-12 | — | — | US | disclosed |
| WO-2017187279-A1 | HEALABLE THERMOPLASTIC RESINS | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2017-11-02 | — | — | WO | disclosed |
| US-20170260333-A1 | POLYETHERIMIDE COMPOSITIONS AND METHODS FOR THE MANUFACTURE AND USE THEREOF | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2017-09-14 | — | — | US | disclosed |
| US-9688816-B2 | Polyetherimide compositions and methods for the manufacture and use thereof | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2017-06-27 | — | — | US | disclosed |
| US-20150133625-A1 | POLYETHERIMIDE COMPOSITIONS AND METHODS FOR THE MANUFACTURE AND USE THEREOF | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2015-05-14 | — | — | US | disclosed |
| US-20130053489-A1 | POLYETHERIMIDE COMPOSITIONS AND METHODS FOR THE MANUFACTURE AND USE THEREOF | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2013-02-28 | — | — | US | disclosed |