Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.40 |
| ▸ | CFTR | P13569 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18419803 | 0.86 | MEN1 (0.43) | ALDH1A1TAAR1CFTRKDM4ESMN1; SMN2 | |
| SCHEMBL9174929 | 0.84 | TAAR1 (0.58) | ALDH1A1TAAR1F2RL1CFTRKDM4E | |
| SCHEMBL11462339 | 0.83 | TAAR1 (0.41) | ALDH1A1TAAR1KDM4EGAAAKR1B1 | |
| Ammonia Solution, Strong SCHEMBL14719474 | 0.82 | TAAR1 (0.56) | ALDH1A1TAAR1F2RL1CFTRKDM4E | |
| SCHEMBL27547823 | 0.81 | TAAR1 (0.45) | ALDH1A1TAAR1GAAAKR1B1SMN1; SMN2 | |
| SCHEMBL3692493 | 0.79 | TAAR1 (0.43) | ALDH1A1TAAR1GAAHPGDAKR1B1 | |
| SCHEMBL3411130 | 0.79 | TAAR1 (0.43) | ALDH1A1TAAR1GAAAKR1B1SMN1; SMN2 | |
| SCHEMBL18568047 | 0.77 | TAAR1 (0.45) | ALDH1A1TAAR1F2RL1CFTRKDM4E | |
| SCHEMBL11507567 | 0.77 | TAAR1 (0.45) | TAAR1F2RL1CFTRHPGDAKR1B1 | |
| SCHEMBL533804 | 0.77 | ALDH1A1 (0.46) | ALDH1A1KDM4EGAAHPGDDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294677-B1 | BENZOPHENONES AND SULFONES AS INHIBITORS OF GLYCINE UPTAKE | PFIZER PROD INC (US) | 2004-11-03 | — | — | EP | disclosed |
| EP-1294677-A1 | BENZOPHENONES AND SULFONES AS INHIBITORS OF GLYCINE UPTAKE | Pfizer Products Inc. (US) | 2003-03-26 | — | — | EP | disclosed |
| US-6506780-B2 | Benzophenones and sulfones as inhibitors of glycine uptake | PFIZER INC. | 2003-01-14 | — | — | US | disclosed |
| US-20020052401-A1 | Benzophenones and sulfones as inhibitors of glycine uptake | PFIZER INC. | 2002-05-02 | — | — | US | disclosed |
| WO-2002000602-A1 | BENZOPHENONES AND SULFONES AS INHIBITORS OF GLYCINE UPTAKE | PFIZER PRODUCTS INC. (US) | 2002-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052401-A1 | Benzophenones and sulfones as inhibitors of glycine uptake | SLC6A1, SLC6A5, SLC1A2 | ALDH1A1 2648/4885TAAR1 669/4885F2RL1 3566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.