SCHEMBL14720136

SCHEMBL14720136

CNCCN(c1ccccn1)c1ccccn1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 3/20 0.62
CYP2D6 P10635 2/20 0.62
HRH3 Q9Y5N1 1/20 0.50
LMNA P02545 3/20 0.49
ALDH1A1 P00352 2/20 0.49
TAAR1 Q96RJ0 1/20 0.49
ALOX15 P16050 1/20 0.49
HDAC1 Q13547 9/20 0.48
HDAC6 Q9UBN7 6/20 0.48
HDAC2 Q92769 5/20 0.48
HDAC3 O15379 2/20 0.48
HDAC4 P56524 2/20 0.48
HDAC5 Q9UQL6 2/20 0.48
TDP1 Q9NUW8 1/20 0.42
HDAC9 Q9UKV0 4/20 0.42
CHRM2 P08172 2/20 0.41
ADRA2A P08913 2/20 0.41
DRD1 P21728 2/20 0.41
SLC6A2 P23975 2/20 0.41
SLC6A4 P31645 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL726956 0.84 CYP2C19 (0.51) CYP2C19CYP2D6HRH3LMNAALDH1A1
Hydrochloric Acid SCHEMBL27281780 0.82 LMNA (0.50) CYP2C19CYP2D6HRH3LMNAALDH1A1
SCHEMBL57491 0.82 CYP2D6 (0.80) CYP2C19CYP2D6LMNAALDH1A1HDAC1
SCHEMBL3387647 0.81 HRH3 (0.46) CYP2C19CYP2D6HRH3LMNAALDH1A1
SCHEMBL17059857 0.80 HRH3 (0.45) CYP2C19CYP2D6HRH3LMNAALDH1A1
SCHEMBL28703873 0.79 CYP2C19 (0.65) CYP2C19CYP2D6ALDH1A1HDAC1HDAC6
SCHEMBL30143833 0.79 CYP2D6 (0.69) CYP2C19CYP2D6LMNAALDH1A1HDAC1
SCHEMBL229946 0.79 CYP2D6 (0.69) CYP2C19CYP2D6LMNAALDH1A1HDAC1
SCHEMBL28366068 0.76 CYP2D6 (0.65) CYP2C19CYP2D6LMNAHDAC1HDAC6
SCHEMBL16491445 0.75 HRH3 (0.44) CYP2C19CYP2D6HRH3LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2744771-B1 C-HALOGEN BOND FORMATION UNIV PRINCETON (US) 2020-10-21 EP claimed
US-20200190012-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2020-06-18 US claimed
US-20140227184-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2014-08-14 US claimed
EP-2744771-A1 C-HALOGEN BOND FORMATION The Trustees of Princeton University (US) 2014-06-25 EP claimed
WO-2013028639-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2013-02-28 WO claimed
EP-2744771-B1 C-HALOGEN BOND FORMATION UNIV PRINCETON (US) 2020-10-21 EP disclosed
US-20200190012-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2020-06-18 US disclosed
US-20190127311-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2019-05-02 US disclosed
US-10196341-B2 C-halogen bond formation THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2019-02-05 US disclosed
US-20160264512-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2016-09-15 US disclosed
WO-2015054476-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2015-04-16 WO disclosed
US-20150031768-A1 C-HALOGEN BOND FORMATION NATIONAL SCIENCE FOUNDATION 2015-01-29 US disclosed
US-20140249329-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2014-09-04 US disclosed
US-20140227184-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2014-08-14 US disclosed
EP-2744771-A1 C-HALOGEN BOND FORMATION The Trustees of Princeton University (US) 2014-06-25 EP disclosed
WO-2013081685-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2013-06-06 WO disclosed
WO-2013028639-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2013-02-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200190012-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 CYP2C19 2559/4885CYP2D6 1756/4885HRH3 714/4885
US-20140227184-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 CYP2C19 2559/4885CYP2D6 1756/4885HRH3 714/4885
US-20160264512-A1 C-HALOGEN BOND FORMATION FOS, BCL3, CBR3 CYP2C19 2701/4885CYP2D6 2159/4885HRH3 1843/4885
US-20190127311-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 CYP2C19 2559/4885CYP2D6 1756/4885HRH3 714/4885
US-20140249329-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 CYP2C19 2559/4885CYP2D6 1756/4885HRH3 714/4885
US-10196341-B2 C-halogen bond formation CBR3, FOS, CBR1 CYP2C19 2559/4885CYP2D6 1756/4885HRH3 714/4885
US-20150031768-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 CYP2C19 2559/4885CYP2D6 1756/4885HRH3 714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.