Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.45 |
| ▸ | DRD1 | P21728 | 3/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30143833 | 1.00 | CYP2D6 (0.69) | CYP2D6CYP2C19KCNH2KCNA5HDAC1 | |
| SCHEMBL28366068 | 0.88 | CYP2D6 (0.65) | CYP2D6CYP2C19KCNH2KCNA5HDAC1 | |
| SCHEMBL57491 | 0.87 | CYP2D6 (0.80) | CYP2D6CYP2C19KCNH2HDAC1HDAC2 | |
| SCHEMBL8011565 | 0.85 | CYP2D6 (0.61) | CYP2D6CYP2C19HDAC1HDAC2HDAC6 | |
| SCHEMBL228938 | 0.85 | CYP2D6 (0.61) | CYP2D6CYP2C19HDAC1HDAC2HDAC6 | |
| SCHEMBL13739154 | 0.85 | CYP2D6 (0.61) | CYP2D6CYP2C19HDAC1HDAC2HDAC6 | |
| SCHEMBL29174424 | 0.85 | CYP2D6 (0.61) | CYP2D6CYP2C19HDAC1HDAC2HDAC6 | |
| SCHEMBL6446263 | 0.83 | CYP2D6 (0.53) | CYP2D6CYP2C19KCNH2KCNA5KCNE1 | |
| SCHEMBL1921570 | 0.83 | CYP2D6 (0.62) | CYP2D6CYP2C19KCNH2KCNA5HDAC1 | |
| SCHEMBL228886 | 0.82 | CYP2D6 (0.57) | CYP2D6CYP2C19KCNH2KCNA5HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859533-B2 | Metalloinsertor complexes targeted to DNA mismatches | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2014-10-14 | — | — | US | claimed |
| US-8182718-B2 | Ligand exchange thermochromic systems and high ε ligands for same | PLEOTINT, L.L.C. (US) | 2012-05-22 | — | — | US | claimed |
| US-20120001134-A1 | LIGAND EXCHANGE THERMOCHROMIC, (LETC), SYSTEMS | PLEOTINT, LLC (US) | 2012-01-05 | — | — | US | claimed |
| US-20090283728-A1 | LIGAND EXCHANGE THERMOCHROMIC, (LETC), SYSTEMS | PLEOTINT, LLC (US) | 2009-11-19 | — | — | US | claimed |
| US-20080100902-A1 | LIGAND EXCHANGE THERMOCHROMIC, (LETC), SYSTEMS | PLEOTINT, LLC (US) | 2008-05-01 | — | — | US | claimed |
| US-9051345-B2 | Metalloinsertor complexes targeted to DNA mismatches | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2015-06-09 | — | — | US | disclosed |
| US-9011734-B2 | Ligand exchange thermochromic, (LETC), systems | PLEOTINT, L.L.C. (US) | 2015-04-21 | — | — | US | disclosed |
| US-8859533-B2 | Metalloinsertor complexes targeted to DNA mismatches | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2014-10-14 | — | — | US | disclosed |
| EP-2707377-A2 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | California Institute of Technology (US) | 2014-03-19 | — | — | EP | disclosed |
| US-20130345189-A1 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-12-26 | — | — | US | disclosed |
| EP-2082005-B9 | LIGAND EXCHANGE THERMOCHROMIC, (LETC), SYSTEMS | PLEOTINT LLC (US) | 2013-05-22 | — | — | EP | disclosed |
| US-8431045-B2 | Ligand exchange thermochromic systems and high ε ligands for same | PLEOTINT, L.L.C. (US) | 2013-04-30 | — | — | US | disclosed |
| US-7542196-B2 | Ligand exchange thermochromic, (LETC), systems | PLEOTINT, L.L.C. (US) | 2009-06-02 | — | — | US | disclosed |
| US-7538931-B2 | Ligand exchange thermochromic systems containing exchange metals | PLEOTINT, L.L.C. (US) | 2009-05-26 | — | — | US | disclosed |
| US-7525717-B2 | reversible; laminated; transition metal ion coordinated with a high epsilon ligand and a low epsilon ligand; polymer; separator; variable light transmission windows; polyvinyl butyral; nickel or cobalt iodide ligands; diol, triol or polyol ligands | PLEOTINT, L.L.C. (US) | 2009-04-28 | — | — | US | disclosed |
| US-20080105851-A1 | Exhibiting a reversible change in absorbance of electromagnetic radiation as the temperature of the system is reversibly changed; comprising a transition metal ion and a ligand | PLEOTINT, LLC (US) | 2008-05-08 | — | — | US | disclosed |
| US-20080106781-A1 | LIGAND EXCHANGE THERMOCHROMIC SYSTEMS CONTAINING EXCHANGE METALS | PLEOTINT, LLC (US) | 2008-05-08 | — | — | US | disclosed |
| US-20080100903-A1 | MULTI-LAYER LIGAND EXCHANGE THERMOCHROMIC SYSTEMS | PLEOTINT, LLC (US) | 2008-05-01 | — | — | US | disclosed |
| US-20080100902-A1 | LIGAND EXCHANGE THERMOCHROMIC, (LETC), SYSTEMS | PLEOTINT, LLC (US) | 2008-05-01 | — | — | US | disclosed |
| WO-2008028128-A1 | LIGAND EXCHANGE THERMOCHROMIC, (LETC), SYSTEMS | PLEOTINT, L.L.C. (US) | 2008-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130345189-A1 | METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES | MSH2, MSH6, PMS2 | CYP2D6 2293/4885CYP2C19 3522/4885KCNH2 4719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.