Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 13/20 | 0.41 |
| ▸ | HTR2C | P28335 | 12/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14722546 | 0.85 | USP2 (0.45) | HTR2AHTR2COGA | |
| SCHEMBL14720486 | 0.81 | NAMPT (0.38) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14721060 | 0.79 | KCNH2 (0.43) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14720887 | 0.79 | POLB (0.52) | ALDH1A1GAALMNAKDM4EMEN1 | |
| SCHEMBL14720731 | 0.78 | ALDH1A1 (0.45) | ALDH1A1GAALMNAKDM4EMEN1 | |
| SCHEMBL23884770 | 0.78 | ALDH1A1 (0.51) | ALDH1A1GAALMNAKDM4EMEN1 | |
| SCHEMBL14721402 | 0.72 | MAPT (0.44) | ALDH1A1LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL14720786 | 0.72 | DRD2 (0.38) | ALDH1A1LMNA | |
| SCHEMBL14731175 | 0.71 | HTR2A (0.66) | ALDH1A1GAALMNAKDM4EMEN1 | |
| SCHEMBL14720768 | 0.70 | KCNH2 (0.44) | ALDH1A1GAAKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |