Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721060 | 0.84 | KCNH2 (0.43) | MEN1KMT2AHPGDHRH3ALDH1A1 | |
| SCHEMBL14720887 | 0.83 | POLB (0.52) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL14720731 | 0.83 | ALDH1A1 (0.45) | MEN1KMT2AHPGDHRH3ALDH1A1 | |
| SCHEMBL14720144 | 0.81 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL14720779 | 0.81 | DDIT3 (0.34) | NAMPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL14720851 | 0.79 | HTR2C (0.39) | NAMPTMEN1 | |
| SCHEMBL14720831 | 0.76 | HRH3 (0.42) | HRH3SRD5A2 | |
| SCHEMBL14721402 | 0.76 | MAPT (0.44) | HPGDHRH3ALDH1A1SMN1; SMN2SRD5A2 | |
| SCHEMBL14720786 | 0.76 | DRD2 (0.38) | HPGDHRH3ALDH1A1SRD5A2 | |
| SCHEMBL14723487 | 0.75 | GPR119 (0.45) | NAMPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |