Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.58 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | GRK2 | P25098 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14152092 | 0.92 | THRB (0.52) | THRBAAK1ALDH1A1NPC1HSD17B10 | |
| SCHEMBL15874474 | 0.80 | THRB (0.52) | THRBAAK1ALDH1A1NPC1POLB | |
| SCHEMBL15874475 | 0.80 | THRB (0.52) | THRBAAK1ALDH1A1NPC1POLB | |
| SCHEMBL14720227 | 0.80 | KMT2A (0.61) | THRBALDH1A1NPC1KMT2ATP53 | |
| SCHEMBL14718338 | 0.80 | AAK1 (0.52) | THRBAAK1NPC1KMT2AMAPT | |
| SCHEMBL18115998 | 0.78 | THRB (0.46) | THRBALDH1A1NPC1POLBKMT2A | |
| SCHEMBL14720195 | 0.76 | USP30 (0.55) | THRBAAK1ALDH1A1NPC1HSD17B10 | |
| SCHEMBL14720615 | 0.76 | DRD2 (0.50) | THRBALDH1A1NPC1KMT2AMAPT | |
| SCHEMBL2298365 | 0.75 | THRB (0.44) | THRBAAK1ALDH1A1NPC1HSD17B10 | |
| SCHEMBL14720196 | 0.75 | HDAC2 (0.46) | THRBAAK1ALDH1A1NPC1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013028445-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |