Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.48 |
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | DTYMK | P23919 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15441571 | 0.81 | YAP1 (0.52) | GPR119POLBHDAC2 | |
| SCHEMBL14721047 | 0.80 | GPR119 (0.42) | GPR119GRM5HDAC2SRD5A1OGA | |
| SCHEMBL14720688 | 0.79 | GPR119 (0.41) | GPR119GRM5HDAC2OGA | |
| SCHEMBL14722713 | 0.78 | GPR119 (0.40) | GPR119GRM5HDAC2OGA | |
| SCHEMBL14720589 | 0.78 | GRM5 (0.43) | GPR119GRM5HDAC2SRD5A1OGA | |
| SCHEMBL14720749 | 0.77 | SRD5A1 (0.58) | GPR119GRM5HDAC2ACHESRD5A1 | |
| SCHEMBL18992022 | 0.77 | OGA (0.45) | GPR119GRM5HDAC2SRD5A1OGA | |
| SCHEMBL14723042 | 0.77 | GRM5 (0.41) | GPR119GRM5POLBHDAC2DTYMK | |
| SCHEMBL1473227 | 0.76 | GPR119 (0.51) | GPR119GRM5GRM1SRD5A1 | |
| SCHEMBL13280881 | 0.76 | PRMT5 (0.49) | GPR119POLBHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |