Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14731055 | 0.97 | HRH3 (0.53) | HRH3HIF1AEPAS1L3MBTL3L3MBTL1 | |
| SCHEMBL14720575 | 0.88 | L3MBTL3 (0.51) | HRH3L3MBTL3L3MBTL1KDM4E | |
| SCHEMBL14721980 | 0.84 | HRH3 (0.43) | HRH3L3MBTL3L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL14721065 | 0.83 | HRH3 (0.41) | HRH3L3MBTL3L3MBTL1KDM4E | |
| SCHEMBL14720643 | 0.82 | OPRM1 (0.41) | HRH3L3MBTL3L3MBTL1SMN1; SMN2 | |
| SCHEMBL14731088 | 0.82 | HRH3 (0.38) | HRH3L3MBTL3L3MBTL1KDM4E | |
| SCHEMBL14720854 | 0.82 | HRH3 (0.40) | HRH3L3MBTL1 | |
| SCHEMBL14721402 | 0.80 | MAPT (0.44) | HRH3L3MBTL3L3MBTL1SMN1; SMN2 | |
| SCHEMBL14721508 | 0.80 | HRH3 (0.38) | HRH3L3MBTL3 | |
| SCHEMBL14722442 | 0.79 | GRM2 (0.47) | HRH3L3MBTL3L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |