Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.35 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720459 | 0.82 | HDAC1 (0.46) | OPRM1OPRD1OPRK1HRH3 | |
| SCHEMBL14720484 | 0.78 | ALDH1A1 (0.58) | OPRM1OPRD1OPRK1 | |
| SCHEMBL14721067 | 0.72 | SRD5A2 (0.42) | KDM2BHRH3L3MBTL3L3MBTL1 | |
| SCHEMBL3926615 | 0.72 | HRH3 (0.68) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL14720723 | 0.72 | KDM2B (0.38) | KDM2BHRH3L3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL1790109 | 0.72 | HRH3 (0.54) | KDM2BHRH3 | |
| SCHEMBL14722010 | 0.71 | GPR119 (0.41) | OPRK1HRH3CHRM2 | |
| SCHEMBL14720838 | 0.70 | SRD5A2 (0.44) | KDM2BHRH3L3MBTL3L3MBTL1 | |
| SCHEMBL3923594 | 0.69 | L3MBTL3 (0.66) | HRH3L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL16702147 | 0.68 | HRH3 (0.57) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |