Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.32 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720672 | 0.87 | HRH3 (0.38) | HRH3CYP2D6SRD5A2 | |
| SCHEMBL14721508 | 0.80 | HRH3 (0.38) | HRH3CYP2D6SRD5A2L3MBTL3 | |
| SCHEMBL14720532 | 0.77 | HRH3 (0.36) | HRH3CYP2D6SRD5A2 | |
| SCHEMBL14721060 | 0.75 | KCNH2 (0.43) | HRH3SRD5A2 | |
| SCHEMBL14721216 | 0.75 | HRH3 (0.40) | HRH3CYP2D6SRD5A2 | |
| SCHEMBL14722982 | 0.74 | SRD5A2 (0.38) | HRH3SRD5A2L3MBTL3 | |
| SCHEMBL14720514 | 0.74 | NAMPT (0.47) | HRH3 | |
| SCHEMBL14720710 | 0.74 | HRH3 (0.56) | HRH3L3MBTL3 | |
| SCHEMBL14722348 | 0.73 | HRH3 (0.38) | HRH3CYP2D6SRD5A2 | |
| SCHEMBL14720817 | 0.73 | SRD5A2 (0.43) | HRH3SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |