Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 11/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14722014 | 0.78 | HRH3 (0.41) | HRH3IRAK4 | |
| SCHEMBL14721988 | 0.74 | KDM2B (0.51) | HRH3IRAK4KDM2BKCNH2 | |
| SCHEMBL14720608 | 0.74 | HRH3 (0.43) | HRH3KCNH2 | |
| SCHEMBL14720518 | 0.73 | HRH3 (0.46) | HRH3 | |
| SCHEMBL14721566 | 0.73 | BRD4 (0.52) | HRH3HSD11B1 | |
| SCHEMBL14722041 | 0.73 | HRH3 (0.52) | HRH3NR1I2 | |
| SCHEMBL14722914 | 0.73 | MAOA (0.39) | HRH3NR1I2 | |
| SCHEMBL14722166 | 0.73 | CYP11B2 (0.42) | HRH3IRAK4KDM2BKCNH2 | |
| SCHEMBL14730970 | 0.72 | ACHE (0.42) | HRH3KCNH2 | |
| SCHEMBL14722409 | 0.71 | NAMPT (0.38) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026453-A1 | TREATMENT OF INFLAMMATORY DISORDERS WITH ANTHRACYCLINES | VALDERM APS (DK) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013026454-A1 | TREATMENT OF CLINICAL CONDITIONS WITH ANTHRACYCLINES | VALDERM APS (DK) | 2013-02-28 | — | — | WO | claimed |
| WO-2013026454-A1 | TREATMENT OF CLINICAL CONDITIONS WITH ANTHRACYCLINES | VALDERM APS (DK) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013026453-A1 | TREATMENT OF INFLAMMATORY DISORDERS WITH ANTHRACYCLINES | VALDERM APS (DK) | 2013-02-28 | — | — | WO | disclosed |