Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168344 | 0.78 | ALDH1A1 (0.46) | ALDH1A1GAASLC6A2HTR2CSLC6A3 | |
| SCHEMBL319460 | 0.74 | CYP1A2 (0.39) | DRD2HTR2AHTR2CHRH1DRD3 | |
| SCHEMBL3772410 | 0.74 | HSD17B3 (0.43) | HSD17B3ALDH1A1GAACHRM2ADRA2A | |
| SCHEMBL5420509 | 0.71 | — | — | |
| SCHEMBL13864441 | 0.69 | ALDH1A1 (0.47) | HSD17B3ALDH1A1GAACHRM2ADRA2A | |
| SCHEMBL15761043 | 0.69 | — | — | |
| SCHEMBL366355 | 0.67 | — | — | |
| SCHEMBL23903 | 0.67 | MAOA (0.41) | ALDH1A1ADRA2ASLC6A2HTR2CSLC6A4 | |
| SCHEMBL6363340 | 0.66 | — | — | |
| SCHEMBL10253628 | 0.66 | HSD17B3 (0.43) | HSD17B3ALDH1A1GAACHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026455-A1 | PERMANENTLY POSITIVELY CHARGED ANTIDEPRESSANTS | AARHUS UNIVERSITET (DK) | 2013-02-28 | — | — | WO | claimed |
| US-20160355511-A1 | NOVEL 1-SUBSTITUTED INDAZOLE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2016-12-08 | — | — | US | disclosed |
| US-9309221-B2 | 1-substituted indazole derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2016-04-12 | — | — | US | disclosed |
| US-20150259344-A1 | IMIDAZOLE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2015-09-17 | — | — | US | disclosed |
| EP-2905279-A1 | IMIDAZOLE DERIVATIVE | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2015-08-12 | — | — | EP | disclosed |
| US-9051295-B2 | 1-substituted indazole derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2015-06-09 | — | — | US | disclosed |
| EP-2837623-A1 | NOVEL 1-SUBSTITUTED INDAZOLE DERIVATIVE | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2015-02-18 | — | — | EP | disclosed |
| US-20150031681-A1 | NOVEL 1-SUBSTITUTED INDAZOLE DERIVATIVE | Sumitomo Pharma Co., Ltd. (JP) | 2015-01-29 | — | — | US | disclosed |
| US-8765786-B2 | 1-substituted indazole derivative | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2014-07-01 | — | — | US | disclosed |
| US-20140121244-A1 | NOVEL 1-SUBSTITUTED INDAZOLE DERIVATIVE | Sumitomo Pharma Co., Ltd. (JP) | 2014-05-01 | — | — | US | disclosed |
| US-20140121243-A1 | NOVEL 1-SUBSTITUTED INDAZOLE DERIVATIVE | Sumitomo Pharma Co., Ltd. (JP) | 2014-05-01 | — | — | US | disclosed |
| WO-2013026455-A1 | PERMANENTLY POSITIVELY CHARGED ANTIDEPRESSANTS | AARHUS UNIVERSITET (DK) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259344-A1 | IMIDAZOLE DERIVATIVE | CHRNA4, CHRNB4, CHRNA7 | HSD17B3 2057/4885ALDH1A1 2889/4885GAA 3268/4885 |
| US-20140121244-A1 | NOVEL 1-SUBSTITUTED INDAZOLE DERIVATIVE | CHRNA3, CHRNB3, CHRNA7 | HSD17B3 218/4885ALDH1A1 2666/4885GAA 4485/4885 |
| US-20160355511-A1 | NOVEL 1-SUBSTITUTED INDAZOLE DERIVATIVE | CHRNA3, CHRNB3, CHRNA7 | HSD17B3 218/4885ALDH1A1 2666/4885GAA 4485/4885 |
| US-20140121243-A1 | NOVEL 1-SUBSTITUTED INDAZOLE DERIVATIVE | CHRNA3, CHRNB3, CHRNA7 | HSD17B3 218/4885ALDH1A1 2666/4885GAA 4485/4885 |
| US-20150031681-A1 | NOVEL 1-SUBSTITUTED INDAZOLE DERIVATIVE | CHRNA3, CHRNB3, CHRNA7 | HSD17B3 218/4885ALDH1A1 2666/4885GAA 4485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.