Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14722534 | 0.84 | LMNA (0.46) | LMNAMAPTTP53HDAC2HDAC3 | |
| SCHEMBL14722283 | 0.78 | LMNA (0.41) | LMNAMAPTABCB1TP53 | |
| SCHEMBL4635083 | 0.77 | GRM5 (0.46) | GRM5GRM1HDAC2HDAC1 | |
| SCHEMBL14720589 | 0.76 | GRM5 (0.43) | GRM5P2RX7TP53HDAC2SRD5A1 | |
| SCHEMBL15699606 | 0.76 | ALDH1A1 (0.54) | GRM5LMNAMAPTABCB1 | |
| SCHEMBL14723605 | 0.75 | TP53 (0.46) | VEGFAEGLN1GRM5LMNATP53 | |
| SCHEMBL18992022 | 0.75 | OGA (0.45) | GRM5TP53HDAC2SRD5A1 | |
| SCHEMBL14720749 | 0.75 | SRD5A1 (0.58) | GRM5HDAC2SRD5A1 | |
| SCHEMBL14723042 | 0.75 | GRM5 (0.41) | VEGFAEGLN1GRM5OPRD1OPRK1 | |
| SCHEMBL14720825 | 0.75 | TP53 (0.46) | VEGFAEGLN1GRM5TP53HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |