Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721926 | 0.87 | POLB (0.39) | MAPTCNR1CNR2ALDH1A1KDM4E | |
| SCHEMBL14722952 | 0.83 | TRPV6 (0.38) | HCRTR2HCRTR1MAPTCNR1CNR2 | |
| SCHEMBL14722534 | 0.82 | LMNA (0.46) | LMNAHCRTR2HCRTR1MAPTALDH1A1 | |
| SCHEMBL14722538 | 0.81 | POLB (0.36) | — | |
| SCHEMBL14723108 | 0.78 | VEGFA (0.46) | LMNAMAPTABCB1TP53 | |
| SCHEMBL14721908 | 0.77 | HRH3 (0.36) | ACHE | |
| SCHEMBL14720875 | 0.74 | FKBP1A (0.38) | — | |
| SCHEMBL14720876 | 0.74 | FKBP1A (0.38) | — | |
| SCHEMBL14731087 | 0.74 | KDM4E (0.42) | LMNACNR2ALDH1A1KDM4E | |
| SCHEMBL14720643 | 0.73 | OPRM1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |