Sugi Predict

Sugi Predict / Compounds / SCHEMBL14723352

SCHEMBL14723352

SCHEMBL14723352

Cc1cc(C2=NOC(c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)O

nearest known ligand 0.43

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ RXRB P28702 2/20 0.43
▸ RXRA P19793 1/20 0.43
▸ RARB P10826 7/20 0.38
▸ RARA P10276 6/20 0.38
▸ RARG P13631 6/20 0.38
▸ PDK2 Q15119 1/20 0.35
▸ CA1 P00915 2/20 0.33
▸ CA2 P00918 2/20 0.33
▸ RORC P51449 2/20 0.33
▸ PDE3B Q13370 1/20 0.31
▸ PDE3A Q14432 1/20 0.31
▸ CRBN Q96SW2 1/20 0.31
▸ MCL1 Q07820 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14723349 1.00 RXRB (0.43) RXRBRXRARARBRARARARG
SCHEMBL31589793 0.93 RXRB (0.42) RXRBRXRARARBRARARARG
SCHEMBL30821396 0.93 RXRB (0.42) RXRBRXRARARBRARARARG
SCHEMBL14721993 0.93 RXRB (0.42) RXRBRXRARARBRARARARG
SCHEMBL14721995 0.93 RXRB (0.42) RXRBRXRARARBRARARARG
SCHEMBL29168436 0.92 RXRB (0.46) RXRBRXRARARBRARARARG
SCHEMBL20492267 0.91 MKNK1 (0.36) RXRBRXRAPDK2CA1CA2
SCHEMBL30309306 0.91 MKNK1 (0.36) RXRBRXRAPDK2CA1CA2
SCHEMBL2014009 0.91 RXRB (0.41) RXRBRXRARARBRARARARG
SCHEMBL12274098 0.91 RXRB (0.41) RXRBRXRARARBRARARARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119161334-A Amide derivative containing thiophene structure, preparation method and application thereof 贵州大学 2024-12-20 — — CN disclosed
WO-2024120137-A1 SUBSTITUTED BENZAMIDE ISOXAZOLINE DERIVATIVE OR AGROCHEMICALLY ACCEPTABLE SALT THEREOF, COMPOSITION, AND USE THEREOF 海利尔药业集团股份有限公司 2024-06-13 — — WO disclosed
CN-118076600-A Compound containing five-membered heterocycle, and preparation method and application thereof 青岛康乔药业集团有限公司 2024-05-24 — — CN disclosed
CN-117886806-A Five-membered heterocyclic compound containing sulfone, and preparation method and application thereof 青岛康乔药业集团有限公司 2024-04-16 — — CN disclosed
CN-115785017-B Substituted benzamide isoxazoline derivative or salt, composition and application thereof as pesticide acceptable 海利尔药业集团股份有限公司 2023-12-08 — — CN disclosed
CN-115785017-A Substituted benzamide isoxazoline derivative or salt thereof acceptable as pesticide, composition and application thereof 海利尔药业集团股份有限公司 2023-03-14 — — CN disclosed
CN-108026089-B Isoxazoline substituted benzamides and analogs as pesticides 先正达参股股份有限公司 2021-10-22 — — CN disclosed
EP-3353171-B1 ISOXAZOLINE-SUBSTITUTED BENZAMIDES AND ANALOGUES AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2021-09-15 — — EP disclosed
US-10588317-B2 Isoxazoline-substituted benzamides and analogues as insecticides SYNGENTA PARTICIPATIONS AG (CH) 2020-03-17 — — US disclosed
US-20180255780-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDES AND ANALOGUES AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2018-09-13 — — US disclosed
CN-104066330-B Isoxazoline derivatives for controlling ectoparasites ANACOR PHARMACEUTICALS, INC. (US) 2016-05-18 — — CN disclosed
US-9247740-B2 Isoxazoline derivatives as insecticidal compounds SYNGENTA PARTICIPATIONS AG (CH) 2016-02-02 — — US disclosed
EP-2782449-A1 ISOXAZOLINE DERIVATIVES USED IN THE CONTROL OF ECTOPARASITES Anacor Pharmaceuticals, Inc. (US) 2014-10-01 — — EP disclosed
US-20140206606-A1 ISOXAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2014-07-24 — — US disclosed
EP-2748155-A1 ISOXAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS Syngenta Participations AG (CH) 2014-07-02 — — EP disclosed
US-8546357-B2 Boron-containing small molecules for controlling ectoparasites ELI LILLY AND COMPANY (US) 2013-10-01 — — US disclosed
WO-2013078071-A1 ISOXAZOLINE DERIVATIVES USED IN THE CONTROL OF ECTOPARASITES ELI LILLY AND COMPANY (US) 2013-05-30 — — WO disclosed
US-20130131017-A1 BORON-CONTAINING SMALL MOLECULES ANACOR PHARMACEUTICALS, INC. (US) 2013-05-23 — — US disclosed
WO-2013026695-A1 ISOXAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2013-02-28 — — WO disclosed
WO-2013026931-A1 ISOXAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2013-02-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140206606-A1 ISOXAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS CHRM1, CHRM3, CHRM2 RXRB 1867/4885RXRA 1816/4885RARB 4645/4885
US-20180255780-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDES AND ANALOGUES AS INSECTICIDES ACHE, CHRM1, NIT2 RXRB 2591/4885RXRA 1905/4885RARB 3028/4885
US-10588317-B2 Isoxazoline-substituted benzamides and analogues as insecticides ACHE, CHRM1, NIT2 RXRB 2591/4885RXRA 1905/4885RARB 3028/4885
US-20130131017-A1 BORON-CONTAINING SMALL MOLECULES BCL6B, BCL6, RB1 RXRB 1224/4885RXRA 3026/4885RARB 1075/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.