Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.51 |
| ▸ | STAMBP | O95630 | 1/20 | 0.51 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13102338 | 0.85 | SMN1; SMN2 (0.62) | ROCK2PSMD14STAMBPCOPS5KDM4E | |
| SCHEMBL1119373 | 0.79 | RAB9A (0.71) | KMT2AADORA2AADORA1NPC1RAB9A | |
| SCHEMBL13118304 | 0.79 | NPC1 (0.60) | ROCK2PSMD14STAMBPCOPS5KDM4E | |
| SCHEMBL1568306 | 0.79 | ROCK2 (0.57) | ROCK2PSMD14STAMBPCOPS5KDM4E | |
| SCHEMBL31468438 | 0.78 | PSMD14 (0.57) | ROCK2PSMD14STAMBPCOPS5KMT2A | |
| SCHEMBL5112470 | 0.78 | MAPK14 (0.63) | MAPK14 | |
| SCHEMBL3643938 | 0.77 | PSMD14 (0.56) | ROCK2PSMD14STAMBPCOPS5KDM4E | |
| SCHEMBL18085951 | 0.77 | ROCK2 (0.58) | ROCK2PSMD14STAMBPCOPS5ADORA2A | |
| SCHEMBL1393311 | 0.77 | NPC1 (0.64) | NR1H4ROCK2PSMD14STAMBPCOPS5 | |
| SCHEMBL13947279 | 0.77 | KDM4E (0.79) | KDM4EKMT2AMAPK14NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |