Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.51 |
| ▸ | STAMBP | O95630 | 1/20 | 0.51 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1568306 | 0.85 | ROCK2 (0.57) | SMN1; SMN2NPC1RAB9AKDM4EROCK2 | |
| SCHEMBL13118304 | 0.85 | NPC1 (0.60) | NPC1RAB9AKDM4EROCK2ADORA2A | |
| SCHEMBL14724679 | 0.85 | NR1H4 (0.53) | SMN1; SMN2NPC1RAB9AKDM4EROCK2 | |
| SCHEMBL1393311 | 0.83 | NPC1 (0.64) | SMN1; SMN2NPC1RAB9AROCK2PSMD14 | |
| SCHEMBL18085951 | 0.83 | ROCK2 (0.58) | NPC1RAB9AROCK2ADORA2APSMD14 | |
| SCHEMBL31468372 | 0.82 | EPHX2 (0.50) | SMN1; SMN2NPC1RAB9AKDM4EROCK2 | |
| SCHEMBL21875133 | 0.80 | GRM4 (0.47) | SMN1; SMN2NPC1RAB9AKDM4EPSMD14 | |
| SCHEMBL2936249 | 0.77 | KDM4E (0.46) | SMN1; SMN2NPC1RAB9AKDM4EPSMD14 | |
| SCHEMBL3223685 | 0.77 | RAB9A (1.00) | SMN1; SMN2NPC1RAB9AKDM4EADORA2A | |
| SCHEMBL31468438 | 0.76 | PSMD14 (0.57) | SMN1; SMN2NPC1RAB9AROCK2PSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349839-B2 | Inhibitors of HIV replication | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-01-08 | — | — | US | disclosed |
| US-20100261714-A1 | INHIBITORS OF HIV REPLICATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261714-A1 | INHIBITORS OF HIV REPLICATION | RTF2, POLR1A, REV1 | SMN1; SMN2 4527/4885NPC1 1005/4885RAB9A 1780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.