Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL792209 | 0.82 | SIGMAR1 (0.49) | ALDH1A1SIGMAR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8259566 | 0.82 | HTR1A (0.55) | HTR1AALDH1A1KDM4ETSHRSIGMAR1 | |
| SCHEMBL6998053 | 0.82 | ALDH1A1 (0.58) | HTR1AALDH1A1KDM4ETSHRSIGMAR1 | |
| SCHEMBL12510959 | 0.79 | KDM4E (0.50) | ALDH1A1KDM4ETSHRSIGMAR1LMNA | |
| SCHEMBL665674 | 0.79 | SIGMAR1 (0.61) | ALDH1A1KDM4ESIGMAR1MEN1POLB | |
| SCHEMBL26384841 | 0.78 | ALDH1A1 (0.54) | HTR1AALDH1A1KDM4ETSHRSIGMAR1 | |
| SCHEMBL16803394 | 0.78 | ALDH1A1 (0.42) | HTR1AALDH1A1KDM4ETSHRSIGMAR1 | |
| SCHEMBL18780865 | 0.77 | SIGMAR1 (0.41) | HTR1AALDH1A1KDM4ETSHRSIGMAR1 | |
| SCHEMBL23269699 | 0.76 | ALDH1A1 (0.51) | ALDH1A1KDM4ETSHRSIGMAR1NPC1 | |
| SCHEMBL12992971 | 0.76 | ALDH1A1 (0.40) | HTR1AALDH1A1KDM4ETSHRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1523473-B1 | INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2013-02-27 | — | — | EP | disclosed |