Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.82 |
| ▸ | RAB9A | P51151 | 9/20 | 0.75 |
| ▸ | NPC1 | O15118 | 8/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.68 |
| ▸ | RELA | Q04206 | 1/20 | 0.68 |
| ▸ | APP | P05067 | 6/20 | 0.66 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.65 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | KDM5A | P29375 | 1/20 | 0.53 |
| ▸ | KDM5C | P41229 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7605200 | 0.90 | NPC1 (0.77) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| Bromide SCHEMBL1691853 | 0.89 | ALDH1A1 (0.80) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| Bromide SCHEMBL1691457 | 0.88 | NPC1 (0.75) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL1691409 | 0.86 | RAB9A (1.00) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL1473062 | 0.85 | NPC1 (0.81) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL1727295 | 0.83 | APP (0.66) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL14076016 | 0.83 | APP (0.66) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL1691526 | 0.83 | APP (0.66) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL5776511 | 0.83 | APP (0.67) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL5302309 | 0.83 | ALDH1A3 (0.75) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160120863-A1 | SLC2A TRANSPORTER INHIBITORS | IOMET PHARMA LTD. (GB) | 2016-05-05 | — | — | US | disclosed |
| US-20160120863-A1 | SLC2A TRANSPORTER INHIBITORS | IOMET PHARMA LTD. (GB) | 2016-05-05 | — | — | US | disclosed |
| US-20160120863-A1 | SLC2A TRANSPORTER INHIBITORS | IOMET PHARMA LTD. (GB) | 2016-05-05 | — | — | US | disclosed |
| EP-3004088-A1 | SLC2A TRANSPORTER INHIBITORS | Iomet Pharma Ltd. (GB) | 2016-04-13 | — | — | EP | disclosed |
| WO-2014187922-A1 | SLC2A TRANSPORTER INHIBITORS | IOMET PHARMA LTD. (GB) | 2014-11-27 | — | — | WO | disclosed |
| WO-2014187922-A1 | SLC2A TRANSPORTER INHIBITORS | IOMET PHARMA LTD. (GB) | 2014-11-27 | — | — | WO | disclosed |
| EP-2262769-B1 | POLYSUBSTITUTED 2-ARYL-6-PHENYL-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-11-05 | — | — | EP | disclosed |
| US-8507520-B2 | Polysubstituted 2-aryl-6-phenylimidazo[1,2-A]pyridine derivatives, and preparation and therapeutic use thereof | SANOFI (FR) | 2013-08-13 | — | — | US | disclosed |
| EP-2262803-B1 | POLYSUBSTITUTED DERIVATIVES OF 2-ARYL-6-PHENYL-IMIDAZO[L,2-A] PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2012-10-17 | — | — | EP | disclosed |
| US-8148370-B2 | Polysubstituted derivatives of 2-aryl-6-phenyl-imidazo[1,2-a]pyridines, and preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2012-04-03 | — | — | US | disclosed |
| US-7915284-B2 | 2-aryl-6-phenylimidazo[1,2-a]pyridine derivatives, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2011-03-29 | — | — | US | disclosed |
| US-20110065745-A1 | POLYSUBSTITUTED 2-ARYL-6-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-03-17 | — | — | US | disclosed |
| US-20110065699-A1 | POLYSUBSTITUTED DERIVATIVES OF 2-ARYL-6-PHENYL-IMIDAZO[1,2-a]PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-03-17 | — | — | US | disclosed |
| EP-2262769-A1 | POLYSUBSTITUTED 2-ARYL-6-PHENYL-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-12-22 | — | — | EP | disclosed |
| EP-2069342-B1 | 2-ARYL-6-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009144394-A1 | POLYSUBSTITUTED 2-ARYL-6-PHENYL-IMIDAZO[L,2- Α] PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-12-03 | — | — | WO | disclosed |
| US-20090253735-A1 | 2-ARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253735-A1 | 2-ARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | NCOR1, NR4A2, NR4A3 | ALDH1A1 1788/4885RAB9A 4133/4885NPC1 781/4885 |
| US-20160120863-A1 | SLC2A TRANSPORTER INHIBITORS | SLCO1A2, SLCO2B1, SLCO2A1 | ALDH1A1 629/4885RAB9A 1287/4885NPC1 137/4885 |
| US-20110065745-A1 | POLYSUBSTITUTED 2-ARYL-6-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF | JAK2, ABL1, REN | ALDH1A1 148/4885RAB9A 1509/4885NPC1 996/4885 |
| US-20110065699-A1 | POLYSUBSTITUTED DERIVATIVES OF 2-ARYL-6-PHENYL-IMIDAZO[1,2-a]PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF | ABL1, JAK2, REN | ALDH1A1 193/4885RAB9A 1452/4885NPC1 1125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.