Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14731288 | 0.88 | CHRNB2 (0.45) | PDE5ACYP11B1CYP11B2MAPTKDM4E | |
| SCHEMBL14731298 | 0.82 | CHRNB2 (0.47) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL14731287 | 0.81 | CYP11B2 (0.45) | CYP11B1CYP11B2KDM4EMAPK1ABCG2 | |
| SCHEMBL16183288 | 0.77 | CYP11B1 (0.40) | PDE5ACYP11B1CYP11B2MAPTKDM4E | |
| SCHEMBL19204123 | 0.74 | CYP11B1 (0.42) | PDE5ACYP11B1CYP11B2MAPTKDM4E | |
| SCHEMBL16184290 | 0.74 | CYP1A2 (0.52) | PDE5AMAPTKDM4ECYP1A2CYP3A4 | |
| SCHEMBL17214445 | 0.74 | PDE5A (0.47) | PDE5ACYP11B1CYP11B2MAPTKDM4E | |
| SCHEMBL14474620 | 0.73 | PDE5A (0.43) | PDE5ACYP11B1CYP11B2MAPTKDM4E | |
| SCHEMBL16183833 | 0.71 | CYP1A2 (0.48) | PDE5AMAPTKDM4ECYP1A2CYP3A4 | |
| SCHEMBL14727666 | 0.69 | CHRNB2 (0.46) | PDE5ACYP11B1CYP11B2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130053341-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL COMPANY (JP) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053341-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP4C, PPP3CB, PTPRG | PDE5A 979/4885CYP11B1 3667/4885CYP11B2 3834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.