SCHEMBL14732018

SCHEMBL14732018

Cc1c(Cc2ccccc2)[c]ccc1C(F)(C(F)(F)F)C(F)(F)F

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 1/20 0.33
MAPT P10636 1/20 0.31
MAPK1 P28482 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3890629 0.76 CALM1 (0.41) CALM1MAPTMAPK1TDP1L3MBTL1
SCHEMBL697977 0.72
SCHEMBL12817027 0.71 CALM1 (0.35) CALM1
SCHEMBL7797745 0.70 ALDH1A1 (0.38) CALM1MAPK1L3MBTL1
SCHEMBL5134623 0.70 LTA4H (0.37) CALM1MAPTMAPK1TDP1L3MBTL1
SCHEMBL8466360 0.69 CALM1 (0.55) CALM1MAPT
SCHEMBL12816980 0.68 IDH1 (0.42) CALM1MAPT
SCHEMBL7453243 0.67 CALM1 (0.42) CALM1MAPTMAPK1TDP1L3MBTL1
SCHEMBL12815447 0.67 SLC6A2 (0.38) CALM1TDP1
SCHEMBL1395580 0.66 CALM1 (0.41) CALM1MAPTTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8389766-B2 Insecticidal compounds SYNGENTA CROP PROTECTION LLC (US) 2013-03-05 US disclosed