Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | SLC27A1 | Q6PCB7 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | GRK2 | P25098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14732160 | 0.88 | TSHR (0.54) | SLC27A1ALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL14732175 | 0.83 | KMT2A (0.43) | SLC27A1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL14732106 | 0.79 | SMN1; SMN2 (0.61) | RORCSLC27A1MEN1KMT2AALDH1A1 | |
| SCHEMBL14732085 | 0.78 | L3MBTL1 (0.51) | MEN1KMT2AALDH1A1TSHRLMNA | |
| SCHEMBL4202684 | 0.72 | LMNA (0.73) | SLC27A1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6406472 | 0.69 | LMNA (0.52) | RORCSLC27A1MEN1KMT2AALDH1A1 | |
| SCHEMBL14732159 | 0.66 | SMN1; SMN2 (0.67) | RORCSLC27A1MEN1KMT2AALDH1A1 | |
| SCHEMBL14732174 | 0.63 | SMN1; SMN2 (0.63) | RORCSLC27A1MEN1KMT2AALDH1A1 | |
| SCHEMBL14732156 | 0.62 | SMN1; SMN2 (0.63) | RORCSLC27A1MEN1KMT2AALDH1A1 | |
| SCHEMBL505220 | 0.62 | RXFP1 (0.69) | MEN1KMT2AALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389739-B1 | Modulators of retinoid-related orphan receptor gamma | Orphagen Pharmaceuticals (US) | 2013-03-05 | — | — | US | disclosed |