Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | SLC27A1 | Q6PCB7 | 5/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | RORC | P51449 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14732159 | 0.87 | SMN1; SMN2 (0.67) | SMN1; SMN2MEN1KMT2ATSHRSLC27A1 | |
| SCHEMBL14732156 | 0.84 | SMN1; SMN2 (0.63) | SMN1; SMN2MEN1KMT2ATSHRKDM4E | |
| SCHEMBL14732174 | 0.84 | SMN1; SMN2 (0.63) | SMN1; SMN2MEN1KMT2ATSHRSLC27A1 | |
| SCHEMBL14732107 | 0.79 | RORC (0.45) | SMN1; SMN2MEN1KMT2ATSHRKDM4E | |
| SCHEMBL14732084 | 0.77 | L3MBTL1 (0.62) | SMN1; SMN2TSHRALDH1A1MAPTMAPK1 | |
| SCHEMBL4202684 | 0.77 | LMNA (0.73) | SMN1; SMN2MEN1KMT2ATSHRKDM4E | |
| SCHEMBL18559373 | 0.76 | SMN1; SMN2 (1.00) | SMN1; SMN2KMT2ATSHRCYP3A4RORC | |
| SCHEMBL13832073 | 0.74 | MEN1 (0.69) | SMN1; SMN2MEN1KMT2ATSHRCYP3A4 | |
| SCHEMBL19368234 | 0.73 | MAPT (0.64) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL13832097 | 0.73 | ALDH1A1 (0.64) | SMN1; SMN2TSHRKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180258133-A1 | MODULATORS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA | ORPHAGEN PHARMACEUTICALS INC (US) | 2018-09-13 | — | — | US | disclosed |
| US-20170267712-A1 | MODULATORS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA | ORPHAGEN PHARMACEUTICALS INC (US) | 2017-09-21 | — | — | US | disclosed |
| US-20170267712-A1 | MODULATORS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA | ORPHAGEN PHARMACEUTICALS INC (US) | 2017-09-21 | — | — | US | disclosed |
| US-9657053-B2 | Modulators of retinoid-related orphan receptor gamma | Orphagen Pharmaceuticals (US) | 2017-05-23 | — | — | US | disclosed |
| US-9657053-B2 | Modulators of retinoid-related orphan receptor gamma | Orphagen Pharmaceuticals (US) | 2017-05-23 | — | — | US | disclosed |
| US-20130150333-A1 | MODULATORS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA | Orphagen Pharmaceuticals (US) | 2013-06-13 | — | — | US | disclosed |
| US-20130150333-A1 | MODULATORS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA | Orphagen Pharmaceuticals (US) | 2013-06-13 | — | — | US | disclosed |
| US-8389739-B1 | Modulators of retinoid-related orphan receptor gamma | Orphagen Pharmaceuticals (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389739-B1 | Modulators of retinoid-related orphan receptor gamma | Orphagen Pharmaceuticals (US) | 2013-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180258133-A1 | MODULATORS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA | RORC, RORB, RORA | SMN1; SMN2 3335/4885MEN1 4608/4885KMT2A 3188/4885 |
| US-20130150333-A1 | MODULATORS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA | RORC, RORB, RORA | SMN1; SMN2 3335/4885MEN1 4608/4885KMT2A 3188/4885 |
| US-20170267712-A1 | MODULATORS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA | RORC, RORB, RORA | SMN1; SMN2 3335/4885MEN1 4608/4885KMT2A 3188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.