Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SLC27A1 | Q6PCB7 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14732160 | 0.89 | TSHR (0.54) | ALDH1A1MAPK1LMNATSHRSLC27A1 | |
| SCHEMBL14732107 | 0.83 | RORC (0.45) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL14732174 | 0.78 | SMN1; SMN2 (0.63) | KMT2AMAPTMEN1CYP3A4ALDH1A1 | |
| SCHEMBL19368234 | 0.69 | MAPT (0.64) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL14732159 | 0.67 | SMN1; SMN2 (0.67) | KMT2AMAPTMEN1CYP3A4ALDH1A1 | |
| SCHEMBL14732156 | 0.66 | SMN1; SMN2 (0.63) | KMT2AMAPTMEN1CYP3A4ALDH1A1 | |
| SCHEMBL4215011 | 0.66 | ALDH1A1 (0.79) | KMT2AMAPTMEN1CYP3A4ALDH1A1 | |
| SCHEMBL20194455 | 0.62 | KCNJ11 (0.59) | KMT2AMAPTMEN1ALDH1A1TSHR | |
| SCHEMBL30640474 | 0.62 | KCNJ11 (0.59) | KMT2AMAPTMEN1ALDH1A1TSHR | |
| SCHEMBL14732106 | 0.62 | SMN1; SMN2 (0.61) | KMT2AMAPTMEN1CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389739-B1 | Modulators of retinoid-related orphan receptor gamma | Orphagen Pharmaceuticals (US) | 2013-03-05 | — | — | US | disclosed |