Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.60 |
| ▸ | PTGES | O14684 | 5/20 | 0.56 |
| ▸ | LPAR1 | Q92633 | 9/20 | 0.52 |
| ▸ | LPAR5 | Q9H1C0 | 9/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.52 |
| ▸ | LTA4H | P09960 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14732137 | 0.82 | LPAR1 (0.44) | SRD5A2PTGESLPAR1LPAR5ALOX5 | |
| SCHEMBL8999835 | 0.81 | SRD5A2 (0.78) | SRD5A2 | |
| SCHEMBL11419154 | 0.77 | SRD5A2 (0.71) | SRD5A2PTGESALOX5 | |
| SCHEMBL14732164 | 0.77 | LPAR1 (0.49) | LPAR1LPAR5 | |
| SCHEMBL200428 | 0.75 | SRD5A2 (0.88) | SRD5A2LTA4H | |
| SCHEMBL1888572 | 0.75 | SRD5A2 (0.88) | SRD5A2LTA4H | |
| SCHEMBL6892687 | 0.75 | SRD5A2 (0.88) | SRD5A2LTA4H | |
| SCHEMBL30307442 | 0.75 | PARP15 (0.69) | SRD5A2KMT2A | |
| SCHEMBL2748100 | 0.75 | PARP15 (0.69) | SRD5A2KMT2A | |
| SCHEMBL31202650 | 0.75 | PARP15 (0.69) | SRD5A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389500-B2 | Fused heterocyclic compounds as ion channel modulators | GILEAD SCIENCES, INC. (US) | 2013-03-05 | — | — | US | claimed |