Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 16/20 | 0.44 |
| ▸ | LPAR5 | Q9H1C0 | 16/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14732192 | 0.82 | SRD5A2 (0.60) | LPAR1LPAR5SRD5A2PTGESALOX5 | |
| SCHEMBL3378390 | 0.78 | FFAR4 (0.43) | SRD5A2PTGESALOX5FFAR4 | |
| SCHEMBL14732164 | 0.78 | LPAR1 (0.49) | LPAR1LPAR5 | |
| SCHEMBL3379807 | 0.73 | PTGES (0.52) | LPAR1LPAR5SRD5A2PTGESALOX5 | |
| SCHEMBL14732180 | 0.69 | NR3C1 (0.50) | SRD5A2 | |
| SCHEMBL3376339 | 0.69 | PTGES (0.58) | LPAR1LPAR5SRD5A2PTGESALOX5 | |
| SCHEMBL14732190 | 0.68 | S1PR1 (0.41) | LPAR1LPAR5SRD5A2PTGES | |
| SCHEMBL8999835 | 0.65 | SRD5A2 (0.78) | SRD5A2 | |
| SCHEMBL7373530 | 0.64 | LMNA (0.43) | — | |
| SCHEMBL2710776 | 0.64 | SRD5A2 (0.65) | SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389500-B2 | Fused heterocyclic compounds as ion channel modulators | GILEAD SCIENCES, INC. (US) | 2013-03-05 | — | — | US | claimed |