Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14734446 | 0.82 | ALDH1A1 (0.47) | MAPTALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL14734356 | 0.80 | RAD52 (0.40) | MAPTALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL4396535 | 0.79 | MAPT (0.52) | MAPTALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL14734437 | 0.79 | MAPT (0.48) | MAPTALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL2412550 | 0.78 | MAPT (0.43) | MAPTALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL4833903 | 0.77 | MAPT (0.54) | MAPTALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL29670121 | 0.77 | ALDH1A1 (0.72) | MAPTALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL2056931 | 0.77 | ALDH1A1 (0.72) | MAPTALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL6387026 | 0.76 | MAPT (0.52) | MAPTALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL2025252 | 0.74 | LMNA (0.57) | MAPTALDH1A1SMN1; SMN2MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027794-A1 | NOVEL COMPOUND AND USE THEREOF AS PDE10 INHIBITOR | 田辺三菱製薬株式会社 (JP) | 2013-02-28 | — | — | WO | disclosed |