Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 6/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14739634 | 1.00 | PTGDR2 (0.39) | PTGDR2SLC6A4KDM4ETBXA2RPTGDR | |
| SCHEMBL7711798 | 0.73 | RHEB (0.39) | PTGDR2SLC6A4KDM4EALDH1A1CYP1A2 | |
| SCHEMBL14738748 | 0.73 | RHEB (0.39) | PTGDR2SLC6A4KDM4EALDH1A1CYP1A2 | |
| SCHEMBL14738750 | 0.73 | RHEB (0.39) | PTGDR2SLC6A4KDM4EALDH1A1CYP1A2 | |
| SCHEMBL830491 | 0.67 | TNKS (0.47) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14738358 | 0.67 | FAAH (0.45) | KDM4ELMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14739233 | 0.66 | KDM4E (0.35) | PTGDR2SLC6A4KDM4ELMNAALDH1A1 | |
| SCHEMBL29856265 | 0.66 | SLC22A12 (0.47) | KDM4ELMNAALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL7713894 | 0.65 | DRD4 (0.44) | LMNACYP1A2CYP3A4HTR6 | |
| SCHEMBL14738737 | 0.65 | LMNA (0.37) | PTGDR2SLC6A4KDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-03-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | FAAH, FAAH2, IDO1 | PTGDR2 168/4885SLC6A4 264/4885KDM4E 307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.