Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4953532 | 0.85 | CXCR4 (0.50) | KMT2ANPC1RAB9ACXCR4 | |
| SCHEMBL31507093 | 0.81 | PRMT5 (0.70) | KMT2ANPC1RAB9APRMT5WDR77 | |
| SCHEMBL12085509 | 0.81 | CXCR4 (0.40) | KMT2APRMT5WDR77CXCR4HDAC6 | |
| SCHEMBL20325080 | 0.80 | KMT2A (0.46) | KMT2ANPC1RAB9APRMT5WDR77 | |
| SCHEMBL10079675 | 0.80 | PRMT5 (0.41) | PRMT5WDR77KCNH2 | |
| SCHEMBL13576643 | 0.80 | KCNH2 (0.53) | KCNH2 | |
| SCHEMBL13576618 | 0.80 | KCNH2 (0.53) | KCNH2 | |
| SCHEMBL3637783 | 0.79 | KMT2A (0.64) | KMT2ANPC1RAB9APRMT5WDR77 | |
| SCHEMBL530604 | 0.79 | CHEK1 (0.44) | — | |
| SCHEMBL13186664 | 0.77 | KCNH2 (0.56) | KMT2AMEN1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013033310-A1 | MODULATORS OF REV-ERB | KAMENECKA THEODORE MARK (US) | 2013-03-07 | — | — | WO | disclosed |