Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.44 |
| ▸ | MEN1 | O00255 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14740818 | 0.85 | STING1 (0.42) | POLBKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL14740816 | 0.85 | HCAR2 (0.40) | POLBKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL14740804 | 0.83 | MEN1 (0.40) | POLBKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL27615911 | 0.75 | WNT3A (0.44) | KMT2AALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27597149 | 0.75 | SERPINE1 (0.43) | POLBKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL27615863 | 0.74 | RAB9A (0.46) | POLBKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL27597136 | 0.73 | SMN1; SMN2 (0.47) | KMT2AMEN1ALDH1A1RAB9ANPC1 | |
| SCHEMBL17336575 | 0.72 | RAB9A (0.43) | KMT2AMEN1ALDH1A1RAB9ANPC1 | |
| SCHEMBL14740844 | 0.71 | MEN1 (0.43) | POLBKMT2AMEN1NPC1MAPT | |
| SCHEMBL7462333 | 0.71 | ERCC5 (0.49) | POLBKMT2AMEN1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751095-A2 | NOVEL BENZODIAZEPINONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR FUNCTIONS AND NEUROLOGICAL USES THEREOF | Sanford-Burnham Medical Research Institute (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033246-A2 | NOVEL BENZODIAZEPINONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR FUNCTIONS AND NEUROLOGICAL USES THEREOF | BRAINCELLS, INC. (US) | 2013-03-07 | — | — | WO | disclosed |