Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14743883 | 0.90 | MAPK1 (0.46) | KDM4EMAPK1HSD17B10ALDH1A1MEN1 | |
| SCHEMBL14743739 | 0.82 | MEN1 (0.48) | KDM4EMAPK1HSD17B10ALDH1A1MEN1 | |
| SCHEMBL14742913 | 0.77 | RAB9A (0.49) | KDM4EMAPK1HSD17B10ALDH1A1MEN1 | |
| SCHEMBL14743740 | 0.76 | ACLY (0.45) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL4241238 | 0.74 | KMT2A (0.68) | KDM4EMAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL7038564 | 0.72 | ACLY (0.67) | KDM4EMAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL11665959 | 0.72 | TSHR (0.77) | KDM4EMAPK1HSD17B10ALDH1A1MEN1 | |
| SCHEMBL8804658 | 0.72 | KDM4E (0.82) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL2275077 | 0.72 | KDM4E (0.66) | KDM4EMAPK1HSD17B10ALDH1A1MEN1 | |
| SCHEMBL2276099 | 0.72 | KDM4E (0.66) | KDM4EMAPK1HSD17B10ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013030358-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-03-07 | — | — | WO | disclosed |