Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 9/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 8/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL28132681 | 0.89 | KDM1A (0.35) | DPP4DPP8 | |
| Bicarbonate SCHEMBL10618281 | 0.84 | CES2 (0.38) | DPP4DPP8FFAR1FFAR4HSD11B1 | |
| Hydrogen Peroxide SCHEMBL28133733 | 0.82 | CES2 (0.30) | CES2CES1 | |
| Acetic Acid SCHEMBL2861217 | 0.80 | HPGD (0.36) | DPP4DPP8FFAR1FFAR4HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL2224472 | 0.80 | DPP4 (0.33) | DPP4DPP8 | |
| Trifluoroacetic Acid SCHEMBL334563 | 0.80 | GABRP (0.39) | DPP4DPP8 | |
| Trifluoroacetic Acid SCHEMBL14737502 | 0.78 | DPP4 (0.33) | DPP4DPP8 | |
| Trifluoroacetic Acid SCHEMBL2394605 | 0.78 | SLC6A1 (0.42) | DPP4DPP8 | |
| Trifluoroacetic Acid SCHEMBL31645392 | 0.78 | DPP4 (0.33) | DPP4DPP8 | |
| Trifluoroacetic Acid SCHEMBL2377040 | 0.78 | SLC6A1 (0.42) | DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |