Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27566114 | 0.85 | CTSL (0.42) | CTSSCTSKCTSLCTSBKMT2A | |
| SCHEMBL4519114 | 0.85 | CTSL (0.42) | CTSSCTSKCTSLCTSBKMT2A | |
| SCHEMBL8173021 | 0.81 | PCSK9 (0.38) | CTSSCTSKCTSLCTSBKMT2A | |
| SCHEMBL2486525 | 0.81 | USP2 (0.44) | CTSSCTSKCTSLCTSBKMT2A | |
| SCHEMBL17251579 | 0.81 | PIK3CD (0.46) | PIK3CDALDH1A1SIGMAR1TDP1 | |
| SCHEMBL17241944 | 0.81 | PIK3CD (0.46) | PIK3CDALDH1A1SIGMAR1TDP1 | |
| SCHEMBL4722765 | 0.76 | GPR119 (0.46) | KMT2AMEN1ALDH1A1TDP1PCSK9 | |
| SCHEMBL14744271 | 0.75 | KMT2A (0.38) | HRH3CTSSCTSKKMT2AMEN1 | |
| SCHEMBL4770333 | 0.75 | PIK3CD (0.41) | PIK3CDCTSKKMT2ASIGMAR1TDP1 | |
| SCHEMBL15859325 | 0.74 | DRD2 (0.55) | ALDH1A1SIGMAR1TDP1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007020194-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |