Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.34 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.34 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14745820 | 0.92 | SMN1; SMN2 (0.38) | PDE3BPDE3ARXFP1 | |
| SCHEMBL14745816 | 0.84 | PDE3B (0.43) | PDE3BPDE3APARP1PARP3RXFP1 | |
| SCHEMBL14745238 | 0.83 | SERPINE1 (0.42) | PDE3BPDE3ADHODHSERPINE1 | |
| SCHEMBL14745499 | 0.83 | PDE3B (0.43) | PDE3BPDE3ADHODHPARP1PARP3 | |
| SCHEMBL14741114 | 0.77 | SERPINE1 (0.42) | PDE3BPDE3ASERPINE1PARP1PARP3 | |
| SCHEMBL14745819 | 0.76 | GSK3B (0.43) | PDE3BPDE3ASERPINE1RXFP1 | |
| SCHEMBL14745775 | 0.75 | CDC7 (0.31) | PDE3BPDE3A | |
| SCHEMBL14745764 | 0.74 | SERPINE1 (0.31) | SERPINE1 | |
| SCHEMBL14741008 | 0.73 | PDE3B (0.52) | PDE3BPDE3ADHODHSERPINE1MDM2 | |
| SCHEMBL14740973 | 0.73 | SERPINE1 (0.47) | DHODHSERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016039936-A2 | MONOCYCLIC SUBSTITUTED 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | claimed |
| EP-2750505-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC Therapeutics, Inc. (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033240-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE | PTC THERAPEUTICS, INC. (US) | 2013-03-07 | — | — | WO | disclosed |